the prophylactic effects of zintoma and ibuprofen on post-endodontic pain of molars with irreversible pulpitis: a randomized clinical trial

introduction : post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. the purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of zingiber officinale , zintoma , and ibuprofen on post endodontic pain of molars with irreversible pulpitis. materials and methods: the post endodontic pain of 72 enrolled patients suffering from irreversible pulpitis was assessed after prophylactic use of 400 mg ibuprofen, 2 gr zintoma and placebo. using the heft-parker visual analogue scale, the patients recorded their perceived pain before taking the medicament (baseline), immediately after and also at 4, 8, 12, 24, 48, and 72 h post one-visit endodontic treatment. the statistical analysis was done using kruskal-wallis, mann-whitney, and freedman tests ( p <0.05). results: at all times, there was significant difference between the ibuprofen and zintoma ( p <0.05) and also between the ibuprofen and placebo ( p <0.05). however, there was no significant difference between zintoma and the placebo in any of time intervals ( p >0.05). no side effects were observed. conclusion: the obtained results of the trial revealed that prophylactic use of 2 gr zintoma is not an effective pain relieving agent.